PENK

Across TCGA cell cohorts, PENK mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PENK-associated genes across cancer lineages are GHRHR, ADRA1A, and PRND. Each is linked with PENK in more than 1 cancer types. Because this analysis shows association rather than direction, both PENK-to-partner and partner-to-PENK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRHR grouped by PENK-low versus PENK-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PENK→partner) and Y-score (partner→PENK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GHRHR →	+0.425	+4.705	<.001	.003	3	1
BLOOD_Leukemia	ADRA1A →	+0.232	+4.705	<.001	.003	3	1
BLOOD_Leukemia	PRND →	+0.006	+4.874	.001	.002	3	1
BLOOD_Leukemia	FAM9A →	+0.014	+4.539	<.001	.007	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.062	+4.539	.001	.007	3	1
BLOOD_Leukemia	OR52M1 →	+0.019	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GHRHR by PENK expression — BLOOD_Leukemia

Explore this box plot interactively →