PDZK1IP1

Across TCGA patient cohorts, PDZK1IP1 mutation is significantly associated with the RNA expression of many other genes, with 497 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDZK1IP1-associated genes across cancer lineages are MIR607, VN1R76P, and IGHVIII-5-1. Each is linked with PDZK1IP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDZK1IP1-to-partner and partner-to-PDZK1IP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR607 grouped by PDZK1IP1-low versus PDZK1IP1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZK1IP1→partner) and Y-score (partner→PDZK1IP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR607 →	+0.437	+5.473	<.001	.005	3	2
BRCA	VN1R76P →	+0.102	+5.721	<.001	.003	3	1
BRCA	IGHVIII-5-1 →	+0.387	+5.409	<.001	.005	3	1
BRCA	IGKV2D-23 →	+0.150	+5.317	.008	.006	3	1
BRCA	MIR4497 →	+0.414	+5.070	<.001	.008	3	1
BRCA	MIR4632 →	+0.609	+5.148	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 497 associations by consensus.

MIR607 by PDZK1IP1 expression — BRCA

Explore this box plot interactively →