PDZK1IP1

Across TCGA pan-cancer cohorts, PDZK1IP1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PDZK1IP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PDZK1IP1 RNA is repressed in tumor relative to normal tissue. In most cancer types PDZK1IP1 is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KICH, THCA, and KIRC are the cancer types where PDZK1IP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDZK1IP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−7.820	<.001	11	view →
THCA	Male	III,IV	+5.135	<.001	11	view →
KIRC	All	II,III,IV	+1.177	<.001	9	view →
LIHC	All	II,III,IV	+2.377	<.001	8	view →
COAD	Female	II,III,IV	+1.315	<.001	8	view →
HNSC	All	III,IV	−1.327	.013	6	view →
BLCA	Male	All	+2.846	<.001	5	view →
LUSC	All	II,III,IV	−1.753	<.001	4	view →
CHOL	All	All	+4.654	<.001	3	view →
ESCA	Female	All	+2.949	.016	2	view →
STAD	All	All	+1.655	.013	2	view →
LUAD	Female	II,III,IV	+1.186	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PDZK1IP1–KICH

Open the KICH breakdown →