PDZD11

Across TCGA patient cohorts, PDZD11 mutation is significantly associated with the RNA expression of many other genes, with 350 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDZD11-associated genes across cancer lineages are COX6CP17, RNU6-389P, and MIR6075. Each is linked with PDZD11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDZD11-to-partner and partner-to-PDZD11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6CP17 grouped by PDZD11-low versus PDZD11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD11→partner) and Y-score (partner→PDZD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	COX6CP17 →	+0.492	+5.080	.005	.008	3	2
COAD	RNU6-389P →	+0.613	+5.017	<.001	.009	3	2
UCEC	MIR6075 →	+0.338	+2.830	.001	.005	3	1
UCEC	MIR6894 →	+0.725	+2.759	<.001	.002	3	1
LIHC	OR11H6 →	+0.042	+5.355	<.001	.005	3	1
LIHC	RNA5SP378 →	+0.414	+5.108	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 350 associations by consensus.

COX6CP17 by PDZD11 expression — COAD

Explore this box plot interactively →