PDZD11

Across TCGA pan-cancer cohorts, PDZD11 RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated PDZD11 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PDZD11 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDZD11 expression acts as an unfavorable survival marker, although some lineages such as OV and BLCA show a favorable association.

UVM, HNSC, and KICH are the cancer types where PDZD11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.303	0.801	<.001	140	view →
HNSC	DFS	Median	II,III,IV	0.224	0.420	<.001	127	view →
KICH	OS	Quartile	II,III,IV	0.369	1.000	<.001	102	view →
PAAD	OS	Tertile	II,III,IV	0.470	0.681	.002	48	view →
ESCA	OS	Tertile	All	0.345	0.632	.001	47	view →
LIHC	OS	Tertile	All	0.590	0.771	<.001	43	view →
KIRP	DFS	Quartile	All	0.803	0.966	<.001	41	view →
MESO	OS	Tertile	All	0.267	0.471	.005	27	view →
UCS	DFS	Tertile	IV	0.239	0.936	.024	24	view →
UCEC	DFS	Quartile	IV	0.326	0.854	.001	24	view →
SARC	DFS	Tertile	All	0.444	0.696	.003	23	view →
LGG	OS	Median	All	0.849	0.937	<.001	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

PDZD11–UVM (DFS)

Open the UVM breakdown →