PDZD11

Across TCGA pan-cancer cohorts, PDZD11 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PDZD11’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PDZD11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PDZD11 is over-expressed in tumor.

KIRC, HNSC, and KIRP are the cancer types where PDZD11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDZD11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+0.839	<.001	12	view →
HNSC	Female	III,IV	+0.802	<.001	12	view →
KIRP	All	II,III,IV	+0.776	<.001	11	view →
LIHC	Female	II,III,IV	+1.504	<.001	9	view →
LUAD	Male	II,III,IV	+1.031	<.001	9	view →
BRCA	All	III,IV	+0.995	<.001	8	view →
COAD	All	II,III,IV	+0.422	<.001	8	view →
LUSC	Female	All	+0.833	<.001	6	view →
STAD	All	All	+0.532	<.001	6	view →
BLCA	All	All	+0.428	.003	6	view →
UCEC	All	All	+0.372	<.001	6	view →
CHOL	Female	All	+2.103	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PDZD11–KIRC

Open the KIRC breakdown →