PDZD11

Across TCGA patient cohorts, PDZD11 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDZD11-associated genes across cancer lineages are Src_pY416, EGFR_pY1068, and PCNA. Each is linked with PDZD11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDZD11-to-partner and partner-to-PDZD11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY416 grouped by PDZD11-low versus PDZD11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD11→partner) and Y-score (partner→PDZD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY416 →	-0.275	-2.986	.048	.037	3	1
UCEC	EGFR_pY1068 →	-0.295	-3.000	.042	.037	1	1
UCEC	PCNA →	+0.319	+3.000	.010	.037	1	1
UCEC	Tuberin →	+0.379	+3.000	.014	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Src_pY416 by PDZD11 expression — UCEC

Explore this box plot interactively →