PDXP

Across TCGA patient cohorts, PDXP mutation is significantly associated with the RNA expression of many other genes, with 1,034 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDXP-associated genes across cancer lineages are RNU6-628P, RNA5SP419, and SMIM28. Each is linked with PDXP in more than 1 cancer types. Because this analysis shows association rather than direction, both PDXP-to-partner and partner-to-PDXP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-628P grouped by PDXP-low versus PDXP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDXP→partner) and Y-score (partner→PDXP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-628P →	+0.527	+2.666	<.001	.001	3	2
UCEC	RNA5SP419 →	+0.718	+2.854	<.001	.001	3	2
UCEC	SMIM28 →	+0.372	+2.370	<.001	.005	3	2
UCEC	RNA5SP414 →	+0.626	+2.577	<.001	.004	3	2
UCEC	VWA1 →	-1.330	-3.437	<.001	.005	3	1
UCEC	PCBP1-AS1 →	+0.729	+3.491	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,034 associations by consensus.

RNU6-628P by PDXP expression — UCEC

Explore this box plot interactively →