PDXP

Across TCGA pan-cancer cohorts, PDXP RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PDXP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PDXP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PDXP is over-expressed in tumor, although a few such as KICH and CHOL show the opposite, repressed pattern.

HNSC, LUAD, and LUSC are the cancer types where PDXP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDXP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.713	<.001	11	view →
LUAD	Female	All	+0.341	<.001	9	view →
LUSC	All	II,III,IV	+0.767	<.001	6	view →
BRCA	Female	All	+0.186	<.001	6	view →
BLCA	Female	All	+0.372	.014	5	view →
KIRC	All	All	+0.229	.007	4	view →
KICH	Female	All	−0.602	<.001	3	view →
LIHC	All	All	+0.388	.009	3	view →
CHOL	All	All	−0.827	.001	2	view →
UCEC	All	All	+0.487	.018	2	view →
THCA	All	II,III,IV	−0.290	.029	2	view →
PRAD	All	All	+0.212	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PDXP–HNSC

Open the HNSC breakdown →