PDSS2

Across TCGA patient cohorts, PDSS2 mutation is significantly associated with the RNA expression of many other genes, with 3,446 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDSS2-associated genes across cancer lineages are RNA5SP93, RN7SKP294, and RN7SL361P. Each is linked with PDSS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDSS2-to-partner and partner-to-PDSS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP93 grouped by PDSS2-low versus PDSS2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDSS2→partner) and Y-score (partner→PDSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNA5SP93 →	+0.886	+5.409	<.001	.001	3	3
COAD	RN7SKP294 →	+0.278	+5.142	<.001	.002	3	3
SKCM	RN7SL361P →	+0.124	+4.680	<.001	.007	3	3
SKCM	RN7SL705P →	+0.296	+5.797	<.001	.001	3	3
UCEC	RNA5SP414 →	+0.472	+2.139	<.001	.005	3	3
COAD	OR4D9 →	+0.168	+5.409	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,446 associations by consensus.

RNA5SP93 by PDSS2 expression — COAD

Explore this box plot interactively →