PDSS2

Across TCGA pan-cancer cohorts, PDSS2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PDSS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PDSS2 RNA is repressed in tumor relative to normal tissue. In most cancer types PDSS2 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and KIRP are the cancer types where PDSS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDSS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.518	<.001	10	view →
KIRC	Male	III,IV	−0.655	<.001	9	view →
KIRP	All	III,IV	−0.623	<.001	6	view →
STAD	All	II,III,IV	+0.499	<.001	6	view →
THCA	Male	II,III,IV	−0.514	<.001	4	view →
CHOL	All	II,III,IV	+0.719	.029	2	view →
READ	Female	All	−0.405	.003	2	view →
LUSC	Male	III,IV	−0.307	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PDSS2–KICH

Open the KICH breakdown →