PDIA3

Across TCGA patient cohorts, PDIA3 protein abundance is significantly associated with the RNA expression of many other genes, with 17,628 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PDIA3-associated genes across cancer lineages are AKAP1, TUB, and PPIB. Each is linked with PDIA3 in more than 6 cancer types. Because this analysis shows association rather than direction, both PDIA3-to-partner and partner-to-PDIA3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDIA3 versus AKAP1 in HNSC, with a Pearson correlation of -0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDIA3→partner) and Y-score (partner→PDIA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AKAP1 →	-0.658	-0.154	.007	.006	2	7
LSCC	TUB →	-1.005	-0.202	<.001	.004	3	5
UCEC	PPIB →	+0.954	+0.267	<.001	.007	2	6
BRCA	FKTN →	-0.414	-0.295	.004	<.001	3	5
LSCC	HDAC5 →	-0.487	-0.228	<.001	<.001	3	5
OV	CEP68 →	-0.693	-0.446	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,628 associations by consensus.

PDIA3 vs AKAP1 — HNSC

Explore this scatter interactively →