PDIA3

Across TCGA pan-cancer cohorts, PDIA3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PDIA3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PDIA3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PDIA3 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where PDIA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDIA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.432	<.001	12	view →
KIRC	Female	IV	+1.115	<.001	12	view →
BLCA	All	All	+0.906	<.001	11	view →
THCA	Male	IV	−1.536	<.001	9	view →
STAD	Male	III,IV	+1.391	<.001	9	view →
LIHC	Female	II,III,IV	+1.065	<.001	8	view →
LUAD	Male	II,III,IV	+0.887	<.001	8	view →
LUSC	Female	All	+1.028	<.001	7	view →
BRCA	All	III,IV	+0.869	<.001	6	view →
CHOL	Male	All	+1.273	<.001	5	view →
UCEC	All	All	+0.830	<.001	4	view →
ESCA	All	All	+0.946	.018	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PDIA3–HNSC

Open the HNSC breakdown →