PDIA3

Across TCGA pan-cancer cohorts, PDIA3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PDIA3 data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PDIA3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PDIA3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PRAD show a favorable association.

HNSC, UVM, and KICH are the cancer types where PDIA3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.594	0.720	<.001	138	view →
UVM	DFS	Median	All	0.419	0.761	<.001	126	view →
KICH	DFS	Quartile	II,III,IV	0.481	1.000	.001	67	view →
KIRP	DFS	Quartile	All	0.836	0.969	.001	64	view →
LGG	OS	Median	All	0.733	0.886	<.001	49	view →
CESC	DFS	Median	All	0.403	0.678	<.001	38	view →
PAAD	DFS	Tertile	II,III,IV	0.240	0.521	.004	35	view →
UCEC	OS	Median	All	0.781	0.559	.004	28	view →
ACC	DFS	Tertile	All	0.270	0.709	.004	20	view →
SCLC	OS	Quartile	All	0.362	1.000	.008	18	view →
LUAD	OS	Median	All	0.778	0.885	.003	13	view →
PRAD	DFS	Quartile	All	0.951	0.896	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PDIA3–HNSC (OS)

Open the HNSC breakdown →