PDIA3

Across TCGA cell cohorts, PDIA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,341 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PDIA3-associated GO terms across cancer lineages are Positive regulation of translational initiation in response to stress, Regulation of protein exit from endoplasmic reticulum, and Positive regulation of protein exit from endoplasmic reticulum. Each is linked with PDIA3 in more than 13 cancer types. Because this analysis shows association rather than direction, both PDIA3-to-partner and partner-to-PDIA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of translational initiation in response to stress grouped by PDIA3-low versus PDIA3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDIA3→partner) and Y-score (partner→PDIA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of translational initiation in response to stress →	+0.201	+1.367	<.001	<.001	3	14
BONE	Regulation of protein exit from endoplasmic reticulum →	+0.143	+0.827	<.001	<.001	3	13
STOMACH	Positive regulation of protein exit from endoplasmic reticulum →	+0.134	+1.130	<.001	<.001	3	13
BONE	Glycoprotein biosynthetic process →	+0.059	+0.968	<.001	<.001	3	13
URINARY_TRACT	Regulation of translation initiation in response to endoplasmic reticulum stress →	+0.131	+0.605	<.001	.008	3	12
OESOPHAGUS	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.095	+0.711	.005	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,341 associations by consensus.

Positive regulation of translational initiation in response to stress by PDIA3 expression — STOMACH

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