PDGFRA

Across TCGA cell cohorts, PDGFRA mutation is significantly associated with the RNA expression of many other genes, with 295 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDGFRA-associated genes across cancer lineages are NPY1R, WDR41, and ALDH6A1. Each is linked with PDGFRA in more than 1 cancer types. Because this analysis shows association rather than direction, both PDGFRA-to-partner and partner-to-PDGFRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPY1R grouped by PDGFRA-low versus PDGFRA-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFRA→partner) and Y-score (partner→PDGFRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NPY1R →	+0.409	+3.212	.002	.006	3	2
SKIN	WDR41 →	+0.596	+3.299	.001	.004	3	2
LARGE_INTESTINE	ALDH6A1 →	+0.966	+3.234	.001	.004	3	2
LARGE_INTESTINE	FAM86B2 →	+0.915	+3.364	<.001	.002	3	2
LARGE_INTESTINE	RCHY1 →	+0.836	+3.364	<.001	.002	3	2
LUNG_NSCLC_LUAD	TCP10L2 →	+0.026	+2.717	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 295 associations by consensus.

NPY1R by PDGFRA expression — SKIN

Explore this box plot interactively →