PDGFRA

Across TCGA pan-cancer cohorts, PDGFRA RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PDGFRA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PDGFRA RNA is repressed in tumor relative to normal tissue. In most cancer types PDGFRA is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and COAD are the cancer types where PDGFRA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDGFRA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.845	<.001	12	view →
KICH	Female	All	−3.706	<.001	10	view →
COAD	Female	II,III,IV	−1.209	<.001	10	view →
KIRP	Female	All	−2.658	<.001	9	view →
THCA	Female	II,III,IV	−1.713	<.001	9	view →
UCEC	All	III,IV	−2.782	<.001	8	view →
BLCA	Male	All	−1.829	<.001	7	view →
LIHC	Male	All	−1.628	<.001	7	view →
BRCA	All	III,IV	−1.274	<.001	6	view →
READ	Female	All	−1.366	.002	2	view →
PRAD	All	All	−0.401	.045	2	view →
LUSC	All	All	−0.423	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PDGFRA–KIRC

Open the KIRC breakdown →