PDGFB

Across TCGA patient cohorts, PDGFB mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDGFB-associated genes across cancer lineages are p62 Lck ligand, ASNS, and Ku80. Each is linked with PDGFB in more than 1 cancer types. Because this analysis shows association rather than direction, both PDGFB-to-partner and partner-to-PDGFB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by PDGFB-low versus PDGFB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFB→partner) and Y-score (partner→PDGFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.442	+2.594	.001	.006	3	2
UCEC	ASNS →	+0.531	+2.321	<.001	.033	3	2
UCEC	Ku80 →	+0.283	+1.598	.006	.044	3	1
UCEC	P-Cadherin →	-0.145	-3.169	.021	.018	3	1
UCEC	PEA-15 →	+0.164	+3.321	.046	.010	3	1
UCEC	Annexin-1 →	+0.593	+3.321	.010	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

p62 Lck ligand by PDGFB expression — UCEC

Explore this box plot interactively →