PDGFB

Across TCGA pan-cancer cohorts, PDGFB RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PDGFB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PDGFB RNA is repressed in tumor relative to normal tissue. In most cancer types PDGFB is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, HNSC, and COAD are the cancer types where PDGFB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDGFB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−2.504	<.001	11	view →
HNSC	Female	IV	+1.938	<.001	11	view →
COAD	All	II,III,IV	+0.703	<.001	11	view →
STAD	Male	II,III,IV	+1.650	<.001	10	view →
LIHC	Female	II,III,IV	+2.288	<.001	9	view →
KIRP	Female	All	−1.428	<.001	9	view →
LUSC	Female	II,III,IV	−2.282	<.001	8	view →
LUAD	Female	All	−1.210	<.001	8	view →
BLCA	Female	IV	+0.736	.003	8	view →
KIRC	Female	All	+0.968	<.001	5	view →
THCA	All	All	+0.538	<.001	4	view →
CHOL	Male	All	+2.686	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PDGFB–KICH

Open the KICH breakdown →