PDGFB

Across TCGA pan-cancer cohorts, PDGFB RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PDGFB data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PDGFB RNA is associated with better overall survival. In most high-consensus cancer types, elevated PDGFB expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRC, MESO, and UVM are the cancer types where PDGFB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.699	0.559	<.001	170	view →
MESO	OS	Median	All	0.422	0.659	<.001	60	view →
UVM	DFS	Median	All	0.469	0.947	.001	58	view →
LUAD	OS	Median	All	0.762	0.854	<.001	51	view →
HNSC	OS	Tertile	All	0.691	0.803	.003	45	view →
BLCA	DFS	Tertile	All	0.183	0.450	.005	45	view →
LGG	DFS	Tertile	All	0.675	0.814	.001	40	view →
CESC	DFS	Tertile	All	0.750	0.896	<.001	36	view →
UCS	DFS	Tertile	IV	0.956	0.250	.024	24	view →
PAAD	OS	Median	II,III,IV	0.510	0.708	.018	24	view →
LUSC	OS	Quartile	All	0.564	0.742	.009	21	view →
COAD	DFS	Quartile	All	0.702	0.884	.003	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PDGFB–KIRC (OS)

Open the KIRC breakdown →