PDGFB

Across TCGA cell cohorts, PDGFB mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDGFB-associated genes across cancer lineages are GFRA4, PRSS54, and OR2B2. Each is linked with PDGFB in more than 1 cancer types. Because this analysis shows association rather than direction, both PDGFB-to-partner and partner-to-PDGFB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by PDGFB-low versus PDGFB-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFB→partner) and Y-score (partner→PDGFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GFRA4 →	+0.022	+5.169	<.001	.005	3	1
LARGE_INTESTINE	PRSS54 →	+0.046	+3.930	<.001	.003	3	1
LARGE_INTESTINE	OR2B2 →	+0.030	+4.347	.003	.001	3	1
LARGE_INTESTINE	KRTAP10-3 →	+0.071	+3.920	<.001	.005	3	1
LARGE_INTESTINE	OOSP4A →	+0.133	+3.793	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GFRA4 by PDGFB expression — BREAST

Explore this box plot interactively →