PDE9A

Across TCGA cell cohorts, PDE9A mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE9A-associated genes across cancer lineages are SERPINA4, OR2AP1, and PPIAL4E. Each is linked with PDE9A in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE9A-to-partner and partner-to-PDE9A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINA4 grouped by PDE9A-low versus PDE9A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE9A→partner) and Y-score (partner→PDE9A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SERPINA4 →	+0.005	+3.930	<.001	.003	3	1
SKIN	OR2AP1 →	+0.010	+4.437	<.001	.004	3	1
SKIN	PPIAL4E →	+0.041	+4.347	.001	.001	3	1
LUNG_NSCLC_LUAD	SCYGR1 →	+0.276	+5.228	<.001	.005	3	1
LARGE_INTESTINE	SH3GL2 →	+1.363	+3.252	<.001	.009	3	1
LARGE_INTESTINE	PCCB →	+0.811	+3.125	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

SERPINA4 by PDE9A expression — SKIN

Explore this box plot interactively →