PDE9A

Across TCGA pan-cancer cohorts, PDE9A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PDE9A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PDE9A RNA is repressed in tumor relative to normal tissue. In most cancer types PDE9A is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, THCA, and KICH are the cancer types where PDE9A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDE9A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	−2.658	<.001	12	view →
THCA	Male	III,IV	+1.881	<.001	10	view →
KICH	Female	II,III,IV	−2.119	<.001	8	view →
KIRC	Male	II,III,IV	−0.734	<.001	8	view →
BRCA	All	III,IV	−1.387	<.001	6	view →
READ	All	All	−2.428	<.001	5	view →
LUAD	All	All	+0.363	.003	5	view →
LIHC	Female	II,III,IV	+1.251	<.001	4	view →
KIRP	All	All	−0.791	<.001	4	view →
LUSC	Male	All	−0.500	.004	4	view →
CHOL	Male	All	+2.459	<.001	3	view →
STAD	All	All	−0.750	.010	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PDE9A–COAD

Open the COAD breakdown →