PDE8A

Across TCGA cell cohorts, PDE8A mutation is significantly associated with the RNA expression of many other genes, with 115 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE8A-associated genes across cancer lineages are SEC14L4, SPTA1, and OR2B2. Each is linked with PDE8A in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE8A-to-partner and partner-to-PDE8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC14L4 grouped by PDE8A-low versus PDE8A-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE8A→partner) and Y-score (partner→PDE8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SEC14L4 →	+0.510	+3.999	<.001	.004	3	1
SOFT_TISSUE	SPTA1 →	+0.319	+3.747	<.001	.008	3	1
SOFT_TISSUE	OR2B2 →	+0.052	+3.882	<.001	.004	3	1
SOFT_TISSUE	CCDC185 →	+0.038	+3.635	<.001	.007	3	1
SOFT_TISSUE	OR52N4 →	+0.062	+3.882	<.001	.004	3	1
SOFT_TISSUE	SNTN →	+0.014	+4.392	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 115 associations by consensus.

SEC14L4 by PDE8A expression — SOFT_TISSUE

Explore this box plot interactively →