Across TCGA patient cohorts, PDE6G mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PDE6G-associated genes across cancer lineages are NUTF2P8, RPL23AP90, and MIR98. Each is linked with PDE6G in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE6G-to-partner and partner-to-PDE6G results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6G→partner) and Y-score (partner→PDE6G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUTF2P8 →	+0.129	+3.567	.003	.005	3	1
UCEC	RPL23AP90 →	+0.611	+3.741	<.001	.006	3	1
UCEC	MIR98 →	+0.509	+3.386	<.001	.008	3	1
SKCM	SLC35F3-AS1 →	+0.226	+4.614	<.001	.006	3	1
SKCM	LINC01519 →	+0.016	+4.385	.002	.008	3	1
SKCM	MTND1P29 →	+0.051	+4.614	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Exploration

PDE6G survival (RNA) · tumor vs normal (RNA) · all PDE6G data types