PDE6B

Across TCGA cell cohorts, PDE6B mutation is significantly associated with the RNA expression of many other genes, with 130 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE6B-associated genes across cancer lineages are SPINK9, CHAT, and SPAM1. Each is linked with PDE6B in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE6B-to-partner and partner-to-PDE6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK9 grouped by PDE6B-low versus PDE6B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6B→partner) and Y-score (partner→PDE6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPINK9 →	+0.027	+3.000	<.001	.003	3	2
LUNG_NSCLC_LUAD	CHAT →	+0.139	+2.882	<.001	.009	3	2
OESOPHAGUS	SPAM1 →	+0.013	+4.906	<.001	.006	3	1
BLOOD_Leukemia	GJE1 →	+0.008	+3.984	<.001	.006	3	1
BLOOD_Leukemia	CLPSL1 →	+0.024	+3.464	<.001	.003	3	1
LARGE_INTESTINE	CBY1 →	+0.531	+3.160	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 130 associations by consensus.

SPINK9 by PDE6B expression — SKIN

Explore this box plot interactively →