PDE6B

Across TCGA pan-cancer cohorts, PDE6B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PDE6B data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PDE6B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PDE6B expression acts as an unfavorable survival marker, although some lineages such as LUAD and BRCA show a favorable association.

LUAD, BRCA, and HNSC are the cancer types where PDE6B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.727	0.600	<.001	104	view →
BRCA	OS	Tertile	IV	0.909	0.237	.002	80	view →
HNSC	DFS	Quartile	All	0.782	0.596	<.001	75	view →
CESC	OS	Median	IV	0.682	0.095	.001	54	view →
LGG	DFS	Median	All	0.655	0.819	<.001	51	view →
UCEC	OS	Quartile	II,III,IV	0.559	0.832	.011	42	view →
SKCM	OS	Quartile	All	0.470	0.180	<.001	33	view →
ACC	OS	Tertile	III,IV	0.412	0.997	.011	24	view →
SARC	OS	Quartile	All	0.927	0.745	<.001	22	view →
KIRC	DFS	Median	IV	0.778	0.400	.002	18	view →
LUSC	OS	Median	III,IV	0.643	0.393	.007	17	view →
KICH	OS	Quartile	III,IV	1.000	0.412	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PDE6B–LUAD (DFS)

Open the LUAD breakdown →