PDE4DIP

Across TCGA patient cohorts, PDE4DIP mutation is significantly associated with the RNA expression of many other genes, with 5,958 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE4DIP-associated genes across cancer lineages are NDUFC1, ENO2, and MRPS27. Each is linked with PDE4DIP in more than 3 cancer types. Because this analysis shows association rather than direction, both PDE4DIP-to-partner and partner-to-PDE4DIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFC1 grouped by PDE4DIP-low versus PDE4DIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4DIP→partner) and Y-score (partner→PDE4DIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFC1 →	+0.241	+1.343	.004	<.001	3	4
SKCM	ENO2 →	+0.885	+3.028	.001	<.001	3	4
UCEC	MRPS27 →	+0.428	+1.606	<.001	<.001	3	4
UCEC	GOT1 →	+0.410	+1.938	<.001	<.001	3	4
UCEC	PIMREG →	+0.689	+2.053	<.001	<.001	3	4
UCEC	CCNB1 →	+0.667	+2.384	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,958 associations by consensus.

NDUFC1 by PDE4DIP expression — UCEC

Explore this box plot interactively →