PDE4DIP

Across TCGA pan-cancer cohorts, PDE4DIP RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PDE4DIP data layer compared with 10 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PDE4DIP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PDE4DIP expression acts as an unfavorable survival marker, although some lineages such as SCLC and SKCM show a favorable association.

UVM, HNSC, and LAML are the cancer types where PDE4DIP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.379	0.890	<.001	54	view →
HNSC	DFS	Quartile	All	0.495	0.761	<.001	43	view →
LAML	DFS	Tertile	All	0.363	0.695	<.001	42	view →
SCLC	DFS	Median	All	0.693	0.409	.001	39	view →
THYM	DFS	Quartile	All	0.469	1.000	.008	31	view →
KICH	DFS	Quartile	II,III,IV	0.454	1.000	.012	29	view →
SKCM	DFS	Quartile	All	0.285	0.162	.006	24	view →
LUSC	DFS	Median	III,IV	0.225	0.814	.004	24	view →
PAAD	OS	Quartile	All	0.676	0.430	.014	23	view →
CESC	DFS	Median	III,IV	0.618	0.827	.020	22	view →
UCS	DFS	Tertile	IV	0.832	0.364	.024	12	view →
OV	DFS	Quartile	All	0.123	0.223	.022	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PDE4DIP–UVM (OS)

Open the UVM breakdown →