PDE4D

Across TCGA patient cohorts, PDE4D mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE4D-associated genes across cancer lineages are BRCA2, Annexin-1, and ERK2. Each is linked with PDE4D in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE4D-to-partner and partner-to-PDE4D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRCA2 grouped by PDE4D-low versus PDE4D-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4D→partner) and Y-score (partner→PDE4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	BRCA2 →	-0.230	-3.000	.006	.034	3	3
UCEC	Annexin-1 →	+0.594	+2.157	<.001	<.001	3	3
UCEC	ERK2 →	+0.140	+1.222	.010	.011	3	2
UCEC	IGFBP2 →	-0.409	-1.415	.027	.040	3	2
UCEC	mTOR_pS2448 →	-0.121	-1.398	.004	.004	3	2
UCEC	N-Ras →	-0.072	-1.041	.032	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

BRCA2 by PDE4D expression — SKCM

Explore this box plot interactively →