Across TCGA patient cohorts, PDE4B RNA expression is significantly associated with the protein abundance of many other proteins, with 15,701 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PDE4B-associated proteins across cancer lineages are WIPF1, ACAP1, and PREX1. Each is linked with PDE4B in more than 7 cancer types. Because this analysis shows association rather than direction, both PDE4B-to-partner and partner-to-PDE4B results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4B→partner) and Y-score (partner→PDE4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WIPF1 →	+0.520	+0.972	<.001	.001	3	8
UCEC	ACAP1 →	+0.608	+0.800	<.001	<.001	3	8
UCEC	PREX1 →	+0.462	+0.600	<.001	.004	3	8
OV	WAS →	+0.538	+1.336	<.001	<.001	3	8
OV	ELMO1 →	+0.449	+0.821	<.001	.001	3	8
UCEC	FERMT3 →	+0.561	+0.574	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,701 associations by consensus.

Exploration

PDE4B survival (RNA) · tumor vs normal (RNA) · all PDE4B data types