Across TCGA pan-cancer cohorts, PDE4B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PDE4B data layer compared with 7 for mutation status and 1 for mass-spec protein.
The strongest signal is observed in uveal melanoma (UVM), where higher PDE4B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PDE4B expression acts as an unfavorable survival marker, although some lineages such as UVM and HNSC show a favorable association.
UVM, HNSC, and SKCM are the cancer types where PDE4B RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.