Across TCGA patient cohorts, PDE4B mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE4B-associated genes across cancer lineages are FoxM1, FOXO3a_pS318_S321, and p27_pT198. Each is linked with PDE4B in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE4B-to-partner and partner-to-PDE4B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4B→partner) and Y-score (partner→PDE4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.205	+1.530	.008	.004	3	3
UCEC	FOXO3a_pS318_S321 →	-0.084	-1.312	.025	.027	3	3
UCEC	p27_pT198 →	+0.079	+1.415	.014	.043	3	3
UCEC	Annexin-1 →	+0.594	+2.662	<.001	<.001	3	3
UCEC	TFRC →	+0.355	+1.321	.026	.012	3	3
UCEC	ATM →	-0.532	-1.754	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Exploration

PDE4B survival (RNA) · tumor vs normal (RNA) · all PDE4B data types