Across TCGA cell cohorts, PDE4B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,940 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDE4B-associated GO terms across cancer lineages are CAMP metabolic process, Regulation of relaxation of cardiac muscle, and Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Each is linked with PDE4B in more than 6 cancer types. Because this analysis shows association rather than direction, both PDE4B-to-partner and partner-to-PDE4B results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4B→partner) and Y-score (partner→PDE4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CAMP metabolic process →	+0.100	+2.507	.006	<.001	3	7
BLOOD_Leukemia	Regulation of relaxation of cardiac muscle →	+0.835	+1.489	<.001	<.001	3	7
SOFT_TISSUE	Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel →	+0.076	+1.761	<.001	<.001	3	7
CNS	CAMP catabolic process →	+0.803	+1.533	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.051	+0.737	.004	.007	3	6
BLOOD_Myeloma	Negative regulation of relaxation of muscle →	-0.334	-1.782	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,940 associations by consensus.

Exploration

PDE4B survival (RNA) · tumor vs normal (RNA) · all PDE4B data types