Across TCGA cell cohorts, PDE4B mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PDE4B-associated genes across cancer lineages are LCE1F, MMD2, and IL26. Each is linked with PDE4B in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE4B-to-partner and partner-to-PDE4B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4B→partner) and Y-score (partner→PDE4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	LCE1F →	+0.166	+4.807	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	MMD2 →	+0.036	+4.736	<.001	.009	3	1
LUNG_NSCLC_LUAD	IL26 →	+0.092	+3.080	<.001	.002	3	1
LUNG_NSCLC_LUAD	TSPAN16 →	+0.045	+2.894	<.001	.004	3	1
LUNG_NSCLC_LUAD	GH2 →	+0.039	+2.959	<.001	.004	3	1
LUNG_NSCLC_LUAD	IL21 →	+0.005	+3.150	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

PDE4B survival (RNA) · tumor vs normal (RNA) · all PDE4B data types