PDE3A

Across TCGA patient cohorts, PDE3A protein abundance is significantly associated with the RNA expression of many other genes, with 13,280 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PDE3A-associated genes across cancer lineages are FAM13C, TAGLN, and MYL9. Each is linked with PDE3A in more than 6 cancer types. Because this analysis shows association rather than direction, both PDE3A-to-partner and partner-to-PDE3A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE3A versus FAM13C in UCEC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE3A→partner) and Y-score (partner→PDE3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM13C →	+0.672	+0.484	.008	.001	3	7
CCRCC	TAGLN →	+1.558	+0.630	<.001	<.001	3	7
GBM	MYL9 →	+0.933	+0.398	<.001	<.001	3	6
COAD	MGP →	+1.754	+0.535	<.001	<.001	3	6
CCRCC	FILIP1 →	+0.807	+0.486	<.001	<.001	3	6
UCEC	CNN1 →	+2.182	+0.447	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,280 associations by consensus.

PDE3A vs FAM13C — UCEC

Explore this scatter interactively →