PDE3A

Across TCGA pan-cancer cohorts, PDE3A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PDE3A data layer compared with 9 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PDE3A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDE3A expression acts as an unfavorable survival marker, although some lineages such as KIRC and UVM show a favorable association.

KIRP, KIRC, and BLCA are the cancer types where PDE3A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	II,III,IV	0.234	0.680	<.001	105	view →
KIRC	DFS	Quartile	All	0.749	0.536	<.001	102	view →
BLCA	OS	Tertile	All	0.523	0.697	<.001	98	view →
LUSC	OS	Median	II,III,IV	0.293	0.516	.001	55	view →
UVM	DFS	Median	All	0.742	0.387	.002	47	view →
ACC	OS	Quartile	II,III,IV	0.344	0.765	.006	46	view →
HNSC	DFS	Tertile	IV	0.647	0.481	.004	25	view →
CESC	DFS	Quartile	All	0.719	0.876	.001	20	view →
SKCM	OS	Tertile	IV	0.512	0.895	.013	16	view →
STAD	OS	Median	All	0.647	0.803	.029	10	view →
DLBC	DFS	Quartile	All	0.516	1.000	.043	8	view →
KICH	DFS	Quartile	II,III,IV	0.528	1.000	.018	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PDE3A–KIRP (DFS)

Open the KIRP breakdown →