PDE3A

Across TCGA patient cohorts, PDE3A protein abundance is significantly associated with the protein abundance of many other proteins, with 18,840 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PDE3A-associated proteins across cancer lineages are PDE3A_S312, COL18A1, and COL15A1. Each is linked with PDE3A in more than 8 cancer types. Because this analysis shows association rather than direction, both PDE3A-to-partner and partner-to-PDE3A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE3A versus PDE3A_S312 in CCRCC, with a Pearson correlation of 0.66.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE3A→partner) and Y-score (partner→PDE3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PDE3A_S312 →	+0.867	+0.737	<.001	<.001	3	9
GBM	COL18A1 →	+0.464	+0.343	<.001	<.001	3	8
GBM	COL15A1 →	+0.604	+0.357	<.001	.003	3	8
UCEC	SYNPO2_S705 →	+1.037	+0.635	<.001	<.001	3	7
CCRCC	THBS3 →	+0.894	+0.641	<.001	<.001	3	7
LSCC	TNS2_S120 →	+0.602	+0.336	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,840 associations by consensus.

PDE3A vs PDE3A_S312 — CCRCC

Explore this scatter interactively →