PDE1C

Across TCGA patient cohorts, PDE1C RNA expression is significantly associated with the protein abundance of many other proteins, with 11,630 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible PDE1C-associated proteins across cancer lineages are PDE1C_S469, SLIT3, and CAVIN2. Each is linked with PDE1C in more than 7 cancer types. Because this analysis shows association rather than direction, both PDE1C-to-partner and partner-to-PDE1C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE1C versus PDE1C_S469 in UCEC, with a Pearson correlation of 0.56.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE1C→partner) and Y-score (partner→PDE1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDE1C_S469 →	+0.992	+0.476	<.001	<.001	3	8
OV	SLIT3 →	+0.753	+0.346	.001	<.001	3	6
LSCC	CAVIN2 →	+0.627	+0.390	<.001	<.001	3	6
BRCA	NES →	+0.582	+0.564	<.001	<.001	3	6
BRCA	SYNM →	+0.939	+0.470	<.001	<.001	3	6
UCEC	TMOD2 →	+0.454	+0.488	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,630 associations by consensus.

PDE1C vs PDE1C_S469 — UCEC

Explore this scatter interactively →