PDE1C

Across TCGA pan-cancer cohorts, PDE1C RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PDE1C data layer compared with 8 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PDE1C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDE1C expression acts as an unfavorable survival marker, although some lineages such as KIRC and PAAD show a favorable association.

KIRP, BLCA, and UCEC are the cancer types where PDE1C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.369	0.663	<.001	116	view →
BLCA	DFS	Tertile	All	0.550	0.689	.001	104	view →
UCEC	DFS	Tertile	All	0.555	0.703	<.001	100	view →
KIRC	DFS	Median	All	0.723	0.545	<.001	76	view →
CESC	DFS	Tertile	All	0.438	0.695	<.001	70	view →
PAAD	OS	Median	All	0.491	0.274	<.001	65	view →
OV	DFS	Median	II,III,IV	0.495	0.582	.005	42	view →
LGG	OS	Median	All	0.731	0.885	<.001	41	view →
UVM	DFS	Quartile	II,III,IV	0.309	0.703	.009	36	view →
LUAD	DFS	Tertile	IV	0.211	0.907	.006	24	view →
UCS	DFS	Median	All	0.395	0.122	.005	24	view →
STAD	DFS	Quartile	All	0.303	0.532	.008	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PDE1C–KIRP (DFS)

Open the KIRP breakdown →