PDE1C

Across TCGA pan-cancer cohorts, PDE1C RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of PDE1C’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PDE1C RNA is repressed in tumor relative to normal tissue. In most cancer types PDE1C is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

LUAD, COAD, and BLCA are the cancer types where PDE1C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDE1C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.551	<.001	11	view →
COAD	All	IV	−0.631	<.001	11	view →
BLCA	Male	III,IV	−2.694	<.001	9	view →
LUSC	Female	II,III,IV	−1.775	<.001	9	view →
THCA	Male	All	+0.776	<.001	9	view →
UCEC	All	III,IV	−2.476	<.001	8	view →
LIHC	Female	II,III,IV	+0.161	<.001	8	view →
KIRP	Male	All	−1.084	<.001	7	view →
STAD	All	All	−0.753	<.001	7	view →
BRCA	All	III,IV	−2.069	<.001	6	view →
KICH	All	All	+1.228	<.001	4	view →
KIRC	All	II,III,IV	−0.338	.007	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

PDE1C–LUAD

Open the LUAD breakdown →