PDE1C

Across TCGA patient cohorts, PDE1C protein abundance is significantly associated with the RNA expression of many other genes, with 3,818 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible PDE1C-associated genes across cancer lineages are CCM2L, CANX, and FHL5. Each is linked with PDE1C in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE1C-to-partner and partner-to-PDE1C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE1C versus CCM2L in CCRCC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE1C→partner) and Y-score (partner→PDE1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CCM2L →	+1.153	+0.607	<.001	<.001	3	3
OV	CANX →	-0.930	-0.888	<.001	<.001	3	3
CCRCC	FHL5 →	+1.297	+0.469	<.001	<.001	3	3
CCRCC	RAMP2 →	+1.035	+0.450	<.001	<.001	3	3
CCRCC	CA4 →	+1.165	+0.310	<.001	.007	3	3
CCRCC	FAM162B →	+1.324	+0.614	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,818 associations by consensus.

PDE1C vs CCM2L — CCRCC

Explore this scatter interactively →