PDE1C

Across TCGA patient cohorts, PDE1C mutation is significantly associated with the RNA expression of many other genes, with 3,283 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE1C-associated genes across cancer lineages are ADNP2, PDHX, and RFC5. Each is linked with PDE1C in more than 3 cancer types. Because this analysis shows association rather than direction, both PDE1C-to-partner and partner-to-PDE1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADNP2 grouped by PDE1C-low versus PDE1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE1C→partner) and Y-score (partner→PDE1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ADNP2 →	+0.503	+1.677	<.001	<.001	3	4
UCEC	PDHX →	+0.359	+1.608	.001	<.001	3	4
UCEC	RFC5 →	+0.357	+1.762	.002	<.001	3	4
UCEC	PAXIP1 →	+0.307	+1.961	.002	.001	3	4
UCEC	STIP1 →	+0.284	+1.387	.006	.001	3	4
UCEC	ELAC2 →	+0.262	+1.473	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,283 associations by consensus.

ADNP2 by PDE1C expression — UCEC

Explore this box plot interactively →