PDE1C

Across TCGA patient cohorts, PDE1C mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE1C-associated genes across cancer lineages are FASN, INPP4B, and 4E-BP1. Each is linked with PDE1C in more than 3 cancer types. Because this analysis shows association rather than direction, both PDE1C-to-partner and partner-to-PDE1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by PDE1C-low versus PDE1C-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE1C→partner) and Y-score (partner→PDE1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FASN →	+0.664	+2.823	.003	.034	3	4
COAD	INPP4B →	-0.327	-3.169	.036	.018	3	3
UCEC	4E-BP1 →	+0.264	+2.584	<.001	<.001	3	3
UCEC	14-3-3_beta →	-0.065	-1.738	.020	.011	3	2
UCEC	eEF2 →	+0.249	+1.106	.013	.020	3	2
COAD	EGFR_pY1068 →	-0.405	-2.309	.003	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

FASN by PDE1C expression — STAD

Explore this box plot interactively →