PDE1C

Across TCGA cell cohorts, PDE1C RNA expression is significantly associated with the go_rna of many other GO terms, with 4,446 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PDE1C-associated GO terms across cancer lineages are Positive regulation of cytoskeleton organization, Negative regulation of Rho protein signal transduction, and Endoplasmic reticulum to Golgi vesicle-mediated transport. Each is linked with PDE1C in more than 9 cancer types. Because this analysis shows association rather than direction, both PDE1C-to-partner and partner-to-PDE1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cytoskeleton organization grouped by PDE1C-low versus PDE1C-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE1C→partner) and Y-score (partner→PDE1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of cytoskeleton organization →	+0.061	+2.361	.003	.003	3	10
BONE	Negative regulation of Rho protein signal transduction →	+0.178	+2.463	<.001	.004	3	10
SKIN	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.077	+3.224	<.001	<.001	3	10
SOFT_TISSUE	Interleukin-11-mediated signaling pathway →	+0.165	+1.230	<.001	<.001	3	10
BONE	Integrin-mediated signaling pathway →	+0.272	+3.645	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Protein activation cascade →	+0.454	+2.748	<.001	.008	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,446 associations by consensus.

Positive regulation of cytoskeleton organization by PDE1C expression — LIVER

Explore this box plot interactively →