PDE1C

Across TCGA cell cohorts, PDE1C mutation is significantly associated with the RNA expression of many other genes, with 248 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PDE1C-associated genes across cancer lineages are KRTAP10-4, DTWD2, and BRICD5. Each is linked with PDE1C in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE1C-to-partner and partner-to-PDE1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-4 grouped by PDE1C-low versus PDE1C-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE1C→partner) and Y-score (partner→PDE1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP10-4 →	+0.021	+4.930	<.001	.008	3	2
SKIN	DTWD2 →	+0.572	+3.321	.002	.003	3	2
SKIN	BRICD5 →	+0.766	+2.588	.001	.004	3	2
SKIN	FANCA →	+0.722	+3.628	.006	<.001	3	2
LUNG_SCLC	C8orf74 →	+0.099	+4.044	<.001	.009	3	2
BLOOD_Leukemia	CSH1 →	+0.042	+4.339	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 248 associations by consensus.

KRTAP10-4 by PDE1C expression — SOFT_TISSUE

Explore this box plot interactively →