PDE1C

Across TCGA cell cohorts, PDE1C mutation is significantly associated with the mutation status of many other genes, with 3,401 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE1C-associated genes across cancer lineages are COL12A1, ADAMTS18, and ADAR. Each is linked with PDE1C in more than 4 cancer types. Because this analysis shows association rather than direction, both PDE1C-to-partner and partner-to-PDE1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL12A1 grouped by PDE1C-low versus PDE1C-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE1C→partner) and Y-score (partner→PDE1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	COL12A1 →	+2.678	+3.652	.006	.006	1	5
LUNG_NSCLC_LUSC	ADAMTS18 →	+4.263	+4.263	.001	.001	1	5
STOMACH	ADAR →	+4.807	+4.807	.008	.008	1	5
LARGE_INTESTINE	HECW2 →	+2.415	+3.510	<.001	<.001	1	5
LARGE_INTESTINE	PCDHGA6 →	+2.514	+3.058	.002	.002	1	5
SKIN	MYH7 →	+2.062	+2.000	.002	.002	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,401 associations by consensus.

COL12A1 by PDE1C expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →