PDE1B

Across TCGA cell cohorts, PDE1B mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE1B-associated genes across cancer lineages are MSGN1, RPL10L, and TAFA1. Each is linked with PDE1B in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE1B-to-partner and partner-to-PDE1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by PDE1B-low versus PDE1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE1B→partner) and Y-score (partner→PDE1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.069	+3.345	<.001	.001	3	1
LARGE_INTESTINE	RPL10L →	+0.169	+3.839	<.001	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.209	+2.688	.003	.008	3	1
LARGE_INTESTINE	EFHC2 →	+0.463	+3.555	.001	.003	3	1
LARGE_INTESTINE	C14orf180 →	+0.140	+2.892	<.001	.003	3	1
LARGE_INTESTINE	MDS2 →	+0.389	+3.392	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MSGN1 by PDE1B expression — LARGE_INTESTINE

Explore this box plot interactively →