PDE1B

Across TCGA pan-cancer cohorts, PDE1B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PDE1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PDE1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PDE1B is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KIRC, KICH, and LUAD are the cancer types where PDE1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDE1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.443	<.001	12	view →
KICH	Male	All	−1.354	<.001	10	view →
LUAD	Male	All	−1.253	<.001	9	view →
UCEC	All	III,IV	−2.324	<.001	8	view →
BLCA	Male	IV	−2.255	.001	8	view →
LUSC	Female	II,III,IV	−1.582	<.001	8	view →
COAD	Female	III,IV	−0.712	<.001	8	view →
BRCA	All	II,III,IV	−1.057	<.001	6	view →
READ	Female	All	−1.101	.007	2	view →
LIHC	Female	II,III,IV	+0.500	.038	2	view →
PRAD	All	All	−0.360	<.001	2	view →
STAD	All	All	−0.601	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PDE1B–KIRC

Open the KIRC breakdown →