PDE12

Across TCGA patient cohorts, PDE12 mutation is significantly associated with the RNA expression of many other genes, with 1,115 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE12-associated genes across cancer lineages are RNU6-694P, RNU6-1118P, and CDKN1A. Each is linked with PDE12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE12-to-partner and partner-to-PDE12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-694P grouped by PDE12-low versus PDE12-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE12→partner) and Y-score (partner→PDE12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-694P →	+0.293	+4.308	<.001	.009	3	2
SKCM	RNU6-1118P →	+0.416	+6.624	<.001	.001	3	2
UCEC	CDKN1A →	+1.079	+2.108	<.001	.003	3	2
BRCA	SPDYE8 →	+0.009	+7.471	<.001	.008	3	1
BRCA	IGKV2-23 →	+0.140	+5.259	<.001	.007	3	1
UCEC	PGAP2 →	+0.508	+3.258	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,115 associations by consensus.

RNU6-694P by PDE12 expression — COAD

Explore this box plot interactively →